St Patrick's Athletic might be sitting on top of the Premier Division table going into this game, although they are taking nothing for granted.
Having lost to Drogheda United in this fixture earlier in the season thanks to an injury-time free-kick from Eoghan Osbourne, the Saints are remaining cautious.
Only winger Gareth Coughlan is unavailable as he continues his recovery from a broken leg.
But new signing Jamie O'Brien could make his debut after joining from Bradford City.
Assistant manager John Gill thinks it is imperative that the Inchicore outfit get the home crowd behind them and ensure they start the game well.
"They've been very close against Drogheda and on both occasions in the league I thought we were unlucky not to come away with a result," said Gill.
"We'll be at home on Friday night and we'll need to take full advantage of that."
Drogheda have a real selection headache ahead of this game as Alan McNally, Corie Treacy, Eric McGill and Paul Crowley are all forced to sit it out due to suspension.
On top of that, Jamie Harris, Darragh McNamara, Brendan McGill and Glen Fitzpatrick are all major doubts. However, midfielder Conor Sinnott could be in line to make his debut.
"St Pat's are a very capable team and they are full of experience and were always going to challenge for the title and they could easily be there come the end of the season," said Drogheda's Director of Football, Darius Kierans.
"Pete [Mahon] has done a great job with the budget that he has been given and they will give us a tough test."